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KMID : 0043320100330111729
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Archives of Pharmacal Research
2010 Volume.33 No. 11 p.1729 ~ p.1733
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Deuteromycols A and B, two benzofuranoids from a Red Sea marine-derived Deuteromycete sp.
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Nawwar Mahmoud
Hussein Sahar
Ayoub Nahla A.
Hashim Amani
Mernitz Gudrun
Cuypers Beate
Linscheid Michael
Lindequist Ulrike
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Abstract
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Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1′-hydroxy-(1′→5″)-2″,3″,4″-trihydroxy-2″,3″-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methyl acetate have been isolated from the ethanol extract of the marine-derived fungal strain MF 003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1D-and 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.
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KEYWORD
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Deuteromycete, Marine-derived fungus, Benzofuranoids A and B
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